Medicine

HPV test tops Pap smear at detecting precancerous cervical changes, study says

HPV test tops Pap smear at detecting precancerous cervical changes, study says

Approved by the FDA in 2014, the HPV test is a relatively new alternative to Pap smears.

The randomized, controlled study - the kind of trial considered the "gold standard" of research - showed that the human papillomavirus test is more sensitive than the Pap smear, a widely used test that has been a standard part of women's preventive health care for decades but has drawbacks.

But HPV testing is thought to have a lower specificity for CIN2+ than cytology screening, which could result in more colposcopies and biopsies being performed - some of which may be unnecessary, says the author of a related but separate JAMA editorial. That's because cases of worrisome cellular changes already had been detected and dealt with after the women were first screened, said lead author Gina Ogilvie, a physician and public health researcher at the University of British Columbia.

The findings were published July 3 in the Journal of the American Medical Association. While neither method was foolproof, the study found that women who originally had the Pap smear were more than twice as likely to have abnormal cells, the article reported. At the end of the four years the women were tested using both tests.

Geographically, North America dominates the Pap smear and HPV testing market followed by Europe. According to the article, the researchers surveyed 5080 women treated for early-stage breast cancer by 377 surgeons in Georgia and Los Angeles between 2013 and 2015. The Pap smear worked, he said, only because women were tested often and because cervical cancer grows slowly. The vaccine is given to teens and young adults, but generations of women are still at risk of cervical cancer because HPV eventually infects most people at some point.

About 13,240 new cases of invasive cervical cancer will be diagnosed in the United States in 2018, according to the American Cancer Society.

However, because all women who were HPV test negative in the study also received a Pap smear, additional cases of early cancer were detected.

More news: Federer, Serena in Wimbledon masterclass as Wozniacki crashes

"Whether it's co-testing or choosing one test over another, it's really important to think about the system in which cervical cancer screening is introduced, and that women are called back and followed-up for an abnormal test, whether it be a Pap smear or an HPV test", Ogilvie said. "This trial. found primary HPV testing detected significantly more CIN3+ and CIN2+ cases in the first round and significantly reduced CIN3+ and CIN2+ rates 48 months later". It adds to a body of research suggesting that HPV testing might be more accurate.

At the beginning of this HPV FOCAL trial, half of the women obtained HPV testing and the other half received Pap smear.

Dr. Carol Mangione, a USPSTF task force member and UCLA professor of medicine says the method of testing comes second to being sure that all women, especially high-prevalence groups like black and Hispanic women, are able to get the testing they need. Some women might not even realize that they are being tested for HPV.

One limitation of the study was that it was done in a specific area of Canada and the findings may not be generalized to other populations.

The new study will probably "help push that along", said Wright of NewYork-Presbyterian/Columbia University Medical Center. That's what some experts believe after a new study found that the HPV test detects precancerous cervical changes earlier and more accurately. "If you tested everyone for HPV in their 20s, they are nearly all going to be positive, but there's going to be all of this intervention that's not needed", she said. The two groups were again tested with both the methods post of 4 years.

Most cervical cancers are caused by a particular strains of the Human papillomavirus, or HPV.

"It's really wonderful, there's no other test that gives us this level of reassurance for that period of time for a cancer", Harper says. Partly because of that, he said, "we're a long way away from replacing the Pap smear".


  • Iran accuses Mujahedeen over Paris rally bomb plot

    Iran accuses Mujahedeen over Paris rally bomb plot

    The agreement saw Iran cut its nuclear production in exchange for the lifting of billions of dollars in sanctions. The Iranian opposition have alongside the people of this country been the main victims of this policy.
    LaVar Ball Guarantees Two Lakers Championships With LeBron James

    LaVar Ball Guarantees Two Lakers Championships With LeBron James

    The Lakers certainly have assets to acquire him, but they need a realistic asking price to seriously considering making the move. Throw in Kawhi Leonard into the equation and the possibilities for a cohesive lineup only become more complex.
    Saudi Arabia Agrees To Pump More Oil to Maintain Balance

    Saudi Arabia Agrees To Pump More Oil to Maintain Balance

    OPEC-member Iran, however, has warned it would not accept other producers reaping the benefits by taking its market share. The announcement was made following a cabinet meeting headed by Saudi Arabia's King Salman bin Abdulaziz Al Saud.
  • Sacha Baron Cohen Teases New Trump Project

    You don't know shit. "My wife, my daughter and my son have my first loyalty and always will", Cohen said . The video is now Cohen's only tweet . "Learn about being amusing ".
    China warns USA  is 'opening fire' on global economy with tariff threat

    China warns USA is 'opening fire' on global economy with tariff threat

    According to the report , the Chinese authorities will allow its tariffs against us products to go into effect starting at 12 a.m. A Reuters analysis found just 1% of the 1,102 categories of products imported from China to the USA are consumer goods.
    Arsene Wenger reveals his three favourites to win World Cup 2018

    Arsene Wenger reveals his three favourites to win World Cup 2018

    Uruguay superstar Edinson Cavani will likely miss their World Cup quarterfinal against France , according to ESPN's Diego Munoz. Tite's men now face Belgium on Friday, while France will entertain Uruguay on the same day.
  • Corpus Christi mother arrested for sale, purchase of 7-year-old child

    Corpus Christi mother arrested for sale, purchase of 7-year-old child

    After further investigation, they found two female children, ages two and three, who were allegedly in the process of being sold. Investigators are still looking into the woman and said there could be additional charges filed against her as well.
    Large study shows drinking coffee could extend your life

    Large study shows drinking coffee could extend your life

    Generally speaking, people who drank two to three cups of coffee every day had a lower risk of death than those who didn't. Coffee habits, complete smoking data and mortality rates for the study participants were taken over that 10 year period.
    Ancer, Molinari share lead at National as Tiger stalls

    Ancer, Molinari share lead at National as Tiger stalls

    The 35-year-old from Turin became the first Italian to win a US PGA event since the late Toney Penna took the 1947 Atlanta Open. He got one back at the 16th, hitting his approach to 5 feet, but then failed to get up and down from a bunker at the 18th.
  • Belgium losing no sleep over Brazil: Kompany

    Belgium losing no sleep over Brazil: Kompany

    "At the moment we're definitely not failing, but there's a level above, which we need to achieve", Kompany said. The victor will bid for a place in the final against either France or Uruguay.
    National Hurricane Center monitoring two tropical disturbances

    National Hurricane Center monitoring two tropical disturbances

    Upper level winds ahead the system are likely to weaken it before it reaches the Leeward or Windward Islands late this weekend. At 1100 AM AST (1500 UTC), the center of Tropical Depression Two was located near latitude 10.2 North, longitude 41.4 West.
    Ohh no! What did this Facebook bug do this time!

    Ohh no! What did this Facebook bug do this time!

    According to Facebook's data, 85 percent of people had only one person on their block list unblocked due to the bug. While the company reports that the bug is now fixed, it admitted that up to 800,000 users were affected by the flaw.