Medicine

Novel pill could replace injections to deliver insulin, says study

Novel pill could replace injections to deliver insulin, says study

Tests in pigs have shown the device is able to successfully deliver insulin in the same quantities that people with type 2 diabetes would typically take.

The capsule contains a tiny needle that is made nearly completely of freeze-dried insulin, and a spring - all held in place by a disc of sugar. Also, the MIT-led team found that the technique can used to deliver other protein drugs too. In 2014, Langer and his colleagues developed a pill with tiny needles that will inject the drug into the stomach lining.

The tip of the needle is fabricated from practically 100 p.c compressed, freeze-dried insulin, utilizing the identical course of used to kind tablets of drugs. As the disk dissolves, the spring releases the needle and injects the drug into the stomach wall.

The abdomen wall has no ache receptors, so the researchers imagine that sufferers wouldn't have the ability to feel the injection.

They created a similar shape for the capsule that can orient itself to ensure the needle is in contact with the lining of the stomach. And for long time researchers have pursued a way to orally control insulin. The small capsule contains a needle of compressed insulin that injects after the capsule reaches the stomach.

Scientists at the Brigham and Women's Hospital in Boston designed this pill, which consists of a biodegradable capsule the size of a chickpea containing an insulin microneedle, according to a press release from the United States center. The researchers were inspired to design the SOMA for the leopard tortoise, an African species that is able to straighten if left on its back.

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The researchers' inspiration was the leopard tortoise that has a shell with a high, steep dome, allowing it to right itself if it rolls onto its back. "Our motivation is to make it easier for patients to take medication, particularly medications that require an injection", " Traverso said. The pill is a variant of its shape made using computer modelling since it allows the capsule to reorient itself in the stomach.

"The way this works is it travels down the esophagus in seconds, it's in the stomach within a few minutes, and then you get the drug", said Traverso, who worked with a team from the lab of MIT inventor Robert Langer and insulin maker Novo Nordisk.

"If a person were to move around or the stomach were to growl, the device would not move from its preferred orientation", Alex Abramson, first author of the study published in Science, said in a statement.

Once the contents from the capsule are released, it passes through the digestive system without any side effects.

Other authors of the paper include Ester Caffarel-Salvador, Minsoo Khang, David Dellal, David Silverstein, Yuan Gao, Morten Revsgaard Frederiksen, Andreas Vegge, Frantisek Hubalek, Jorrit Water, Anders Friderichsen, Johannes Fels, Rikke Kaae Kirk, Cody Cleveland, Joy Collins, Siddartha Tamang, Alison Hayward, Tomas Landh, Stephen Buckley, Niclas Roxhed, and Ulrik Rahbek. MIT teamed up with pharmaceutical company Norvo Nordisk for the research.


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