Medicine

Has a second person with HIV been cured?

Has a second person with HIV been cured?

Both the first patient to be cured of H.I.V., Timothy Ray Brown, who is now 52 and was cured in 2007, and the new patient, whom scientists refer to as the "London patient", were afflicted with forms of cancer and were given bone-marrow transplants meant to treat their cancers, not the H.I.V virus, according to The New York Times.

Professor Eduardo Olavarria of Imperial College Healthcare NHS Trust and Imperial College London, said: "While it is too early to say with certainty that our patient is now cured of HIV, and doctors will continue to monitor his condition, the apparent success of stem cell transplantation offers hope in the search for a long-awaited cure for HIV/AIDS".

The UK researchers say it may be possible to use gene therapy to target the CCR5 receptor in people with HIV, now they know the Berlin patient's recovery was not a one-off. "After 10 years of not being able to replicate (the first case), people were wondering if this was a fluke", said lead author Ravindra Gupta, a professor at the University of Cambridge.

While a combination of chemotherapies put the cancer into remission, the doctors had by this point identified an unrelated individual that was a good match for the patient, and carried mutations that can block HIV infection. After 18 months off the drugs, there was still has no trace of HIV, the AP reported.

Brown said he would like to meet the London patient and would encourage him to go public because "it's been very useful for science and for giving hope to HIV-positive people, to people living with HIV", he told The Associated Press Monday.

Sixteen months after the procedure (which notably didn't include radiotherapy, unlike the Berlin patient), the London patient discontinued ARV drugs (aka ART therapy), and has now been in HIV remission for over 18 months.

Читайте также: Brie Larson Is a Superheroine Breaking Free From a Life Following Orders

The treatment is risky, complex and expensive, researchers have said. Infected people still have reservoirs of virus in their bodies, raising the prospect that a drug-resistant strain could ultimately evolve.

Still, no one is arguing this will be a practical way to treat HIV in the millions of people around the world who are living with it. The first, the Berlin Patient, also received a stem cell transplant from a donor with two of the CCR5 alleles, but to treat leukaemia.

A person with HIV from Britain appears to be free of the virus after receiving a stem-cell transplant. So when these donor stem cells repopulated the London patient's blood, H.I.V. was unable to enter the new cells.

"I think that one thing we've learned is finding a scalable, economically feasible cure, or HIV remission, is going to be hard", said Timothy Henrich, an infectious disease specialist at the University of California, San Francisco.

Gupta said that while a second successful transplant did not constitute a generalised cure, it showed that even milder forms of treatment can achieve full remission. "If you're well, the risk of having a bone-marrow transplant is far greater than the risk of staying on tablets every day", he says. His drug regiment was much less harsh than the only other known patient who was cured of HIV.

The transplant led to complete lymphoma remission and testing showed that the man's CD4 T cells now lack CCR5 receptors. He was then treated with radiation and chemotherapy in order to erase his immune system so it could be reconstituted with donated stem cells taken from a donor who was immune to HIV.

При любом использовании материалов сайта и дочерних проектов, гиперссылка на обязательна.
«» 2007 - 2019 Copyright.
Автоматизированное извлечение информации сайта запрещено.

Код для вставки в блог


  • B.C. - most of it - is springing forward an hour this weekend

    B.C. - most of it - is springing forward an hour this weekend

    States and territories that don't now observe DST, including most of Arizona , Hawaii and Puerto Rico , would not have to change. The bills state that all time zones in Texas would be exempt from the law that establishes daylight-saving time .
    Paul Manafort to be sentenced Thursday; faces 25 years in prison

    Paul Manafort to be sentenced Thursday; faces 25 years in prison

    Ellis presided over Manafort's trial and was preparing to hand down his punishment for bank and tax fraud . Now Manafort faces as many as 24 years in prison and millions of dollars in financial penalties.
    Google releases fix for zero-day exploit in Chrome

    Google releases fix for zero-day exploit in Chrome

    If you are reading this, there is a good chance you are doing so on a Chrome browser , based on the available market share data. Chrome users are urged to check their browser to confirm they are running version 72.0.3626.121.
  • Trump suggests signing new trade deal with China

    Trump suggests signing new trade deal with China

    Trump wrote on Twitter on Friday that he had asked Chinese President Xi to "immediately" lift tariffs on US agricultural products. Despite the trade woes in the 2017/2018 marketing year, farmers exported a record 2.6 billion bushels of US soy and soy products.
    Solari set to be sacked and Mourinho is back in the mix

    Solari set to be sacked and Mourinho is back in the mix

    Now, pressure is mounting of Santiago Solari in the dugout with the club unlikely to keep him in place for the 2019/20 campaign. The Spaniard only took over in October but, according to Goal , he won't be in the job much longer.
    Zion Williamson sets internet ablaze with possible Nike jab

    Zion Williamson sets internet ablaze with possible Nike jab

    Williamson originally suffered the injury less than 40 seconds into Duke's first matchup against North Carolina on February 20. Williamson suffered a freak injury during the team's game against North Carolina and hasn't played since.
  • Snow predicted in northern parts of the United Kingdom  for Sunday

    Snow predicted in northern parts of the United Kingdom for Sunday

    What are the chances of low-level snow? Wintry showers will start to spread across much of the country this month. Highest temperatures will be from 4 to 7 degrees with fresh, gusty westerly winds, strong in coastal areas.
    Samsung to release wireless earphones for Galaxy S10

    Samsung to release wireless earphones for Galaxy S10

    Under the hood, the new Galaxy S10 devices are powered by 8nm octa-core in-house developed Exynos 9820 SoC for the Indian market. Users will be able to capture body movement using the rear camera or the movement of the top only with the front camera.
    Huawei Exec Casually Confirms Crazy Periscope Camera As A P30 Novelty

    Huawei Exec Casually Confirms Crazy Periscope Camera As A P30 Novelty

    The imagery that Huawei provided in the course of the press convention prompt that the Mate X would even have a quad-lens digicam. The exec also said that the P30 Pro's camera would do 'something nobody has done before, ' without elaborating on new features.
  • Amazon to enter grocery store arena

    Amazon to enter grocery store arena

    Stock prices of companies like Kroger , Costco , Sprouts, and Walmart, immediately reacted following the spread of the news. Amazon is now evaluating opening dozens of the stores across the USA with the first potentially opening in Los Angeles.
    Guide: How to Use a PS4 Controller with Remote Play on iOS

    Guide: How to Use a PS4 Controller with Remote Play on iOS

    While the DualShock 4 controller's touchpad is helpful for inputting text on PS4, it's hard to beat an actual digital keyboard. You can now change the button assignment to perform "Enter" operations from the O button to the X button.
    Washington Redskins acquire another quarterback from Denver Broncos

    Washington Redskins acquire another quarterback from Denver Broncos

    The Washington Redskins are working on a deal with the Denver Broncos for quarterback Case Keenum , NFL Network reports. In Keenum's lone season with the Broncos, the 31-year-old threw for 3,890 yards and 18 touchdowns to 15 interceptions.